Lipids (Fat Emulsion)

What Are Lipids
Lipids (Fat Emulsion)

Lipids (Fat Emulsion)

Intralipids 20% (20% IV Fat Emulsion) (A 20% Intravenous Fat Emulsion) is a sterile, non-pyrogenic fat emulsion prepared for intravenous administration as a source of calories and essential fatty acids. It is made up of 20% Soybean oil, 1.2% Egg yolk phospholipids, 2.25% Glycerin, and water for injection. In addition, Sodium Hydroxide has been added to adjust the pH so that the final products range is 8.

  • Liconoleic Acid:(Omega-3/6) Keeps the skin impermeable to water.
  • Arachidonic Acid: Created from the breakdown of Liconoleic Acid; can form prostoglandins which help with clotting, induce inflammation and cause smooth muscle contraction. In alternative pathways it can also form leukotrienes, which are one of the most potent inflammatory agents in the human body.
  • Oleic Acid: (Omega-9)Facilitates wound healing, some studies suggest benefits towards cancer, autoimmune and inflammatory disease.
  • Palmitic Acid: Antioxidant; can raise cholesterol levels by itself, however this is prevented when it is combined with Linoleic Acid.
  • a-Linolenic Acid: (Omega-3) Reduce inflammation, may help prevent heart disease and arthritis, lower cholesterol, reduce blood pressure, and decrease inflammation due to asthma; may be important for brain health and development, as well as normal growth and development.
Chemical Structure

The major component fatty acids are linoleic acid (44-62%), oleic acid (19-30%), palmitic acid (7-14%), α-linolenic acid (4-11%) and stearic acid (1.4-5.5%).1 These fatty acids have the following chemical and structural formulas:

Linoleic acid
C18H32O2
Oleic acid
C18H34O2
Palmitic acid
C16H32O2
α-Linolenic acid
C18H30O2
Stearic acid
C18H36O2
Administering
  • Administer through a PICC/Central Line
  • Must have filter on line

References

Mestrovic, T. (2014, December 16). What is Linoleic Acid? News Medical. Retrieved from http://www.news-medical.net/health/What-is-Linoleic-Acid.aspx

Alpha-Linolenic Aicd (2014) University of Maryland Medical Center. Steven D. Ehrlich, NMD, Solutions Acupuncture, a private practice specializing in complementary and alternative medicine, Phoenix, AZ. Review provided by VeriMed Healthcare Network. Also reviewed by the A.D.A.M. Editorial team.